Clinical studies in patients with IBD (inflammatory bowel disease) has shown significant positive effects when supplementing conventional treatment with AndoSan™. A marked improvement in clinical parameters, as well as a significant reduction of the inflammation marker calprotectin in feces, has been shown. Furthermore, a study on colon cancer in mice showed a significantly better development for mice receiving AndoSan™ in the drinking water. As recent research has revealed close links between bacterial flora in the gut and conditions such as IBD and intestinal cancer, we have reason to suspect that AndoSan™ is likely to affect the intestinal flora in a positive direction. Documenting such a connection would open up for introducing AndoSan™ into a rapidly growing segment of the health supplements market as well as point out directions for new areas of medical research involving AndoSan™. ImmunoPharma has therefore chosen to conduct an animal pilot study on the effects of AndoSan™ on intestinal flora in mice cooperation with researchers at Shinshu University in Japan. The study will analyze the effects of AndoSan™ on the intestinal flora of mice to look for changes of immunity in intestine tissue and in the spleen. This analysis will help the researchers to evaluate bioregulatory properties of AndoSan™ in the domain of gut flora with particular emphasis on IBD modeling.
Hippocrates, the father of modern medicine, used to say that “All disease begins in the gut.” Although humans have evolved to live with microbes for millions of years, the impact of gut microbiota on human health and well-being is of great importance to many aspects of health like the immune system, heart, and weight. It would be very difficult to survive without the gut microbiome.
It is estimated that the human gastrointestinal tract contains approximately 100 trillion microorganisms with a total weight of as much as 1–2 kg, which is comparable to the weight of a human brain. The total of bacterial genes in the intestines number around 150 million which is approximately 150 times the number of protein-coding genes in the human body.
Gut microbiota with over three million genes, i.e., 150 times more than human genes, function as a virtual organ of the body and influence the host’s fitness, phenotype, and wellbeing. The higher the microbiome diversity, the better for your health.
The mix of bacteria in our guts is like an individual identity card, unique from everyone else’s mix. It depends partly upon the mother’s microbiota and the environment that one is exposed to at birth, and partly upon diet and lifestyle.
The number and composition of gut bacteria can affect human health in a number of ways, both physically and mentally. Some of the functions of friendly intestinal microbiota include ensuring proper digestive functioning by helping the body to digest certain foods that the stomach and small intestine have not been able to digest. The gut microbiome also provides crucial signals for the development and function of the immune system. By communicating with immune cells, the gut microbiome can control how your body responds to infection and perform a barrier effect. Moreover, intestinal flora helps to combat aggression from other microorganisms and toxins, maintain the integrity of the bowel mucosa and regulate intestinal permeability. New research suggests that the intestinal microbiome may also affect the central nervous system – possibly through neural, endocrine and immune pathways – and have an impact on the proper functioning of the brain, thus playing a role in the regulation of anxiety, mood, cognition, and pain.
The loss of balance between the healthy and unhealthy microbes in the intestines is called gut dysbiosis. It may contribute to obesity (weight gain), diabetes (high blood sugar), high cholesterol and other health problems such as allergies and functional bowel disorders like irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and leaky gut syndrome. The etiology of IBD is partly attributed to a deregulated immune response to gut microbiome dysbiosis. An imbalance in gut microbiota may entail bloating, cramps and abdominal pain that people with IBS experience.